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Other interactions require localbending and folding of the DNA round the initiation complexandthepositionofthe regulatory element is more flex-tibhlies appliesto many eukaryotic transcription factorsboundtotheupstream promoter regionT.
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Perhaps the first step in approaching CHAPTER 2 Structural and Energetic Basis of Molecular Recognition 13 tools can significantly expand the range of problems that can be addressed. IMPURITIES Other detectable impurities (the following substances would, if present at a sufficient level, be detected by one or other of the tests in the monograph.
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