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1, osteoclast differentiation role, 198 R RA, see Retinoic acid Binarry, mechanotransduction in bone cells, 271 osteoclast differentiation role, 200 Rb, see Retinoblastoma protein Receptor tyrosine kinase-like orphan, mutation in skeletal disease, 26 Retinoblastoma protein (Rb), regulation of Smad Binar in Rating Binary Option Platform CAD/JPY differentiation, 188 Retinoic acid (RA), binding Rating Binary Option Platform CAD/JPY, 147, 148, 150 cartilage growth regulation overview, 231 chondrogenesis and retinoid signaling, growth plate chondrocyte signaling, 154, 155 long bone development orchestration with Indian hedgehog, 159162, 166169 molecular mechanisms, 153, 154 overview, 149, 150, 162165 retinoic acid receptor signaling and establishment of chondrogenic template in developing limb, 150152 Hox gene response elements, 148, 154 negative regulation of perichondrial cartilage growth, 242, 244, 246 receptor types, 147 Risk assessment, see Skeletal toxicology ROR2, mutation in skeletal disease, 26 RUNX2, see Cbfa1 RussellSilver syndrome, S sFRP proteins, Wnt binding and regulation, 121, 122 Shwachmandiamond syndrome, candidate gene loci, 29 Skeletal toxicology, adverse in utero embryofetal outcomes, developmental delays or growth retardation, 390 fetal malformations and variations, 390 functional deficits, 390 prenatal death, 390 end points in hazard- and risk-based studies, 404, 405 fetal malformations and variations, classification, 390392 term rodent skeletal components and historical control incidences, 392395, 397404 hazard-based study characteristics, 404, 405 observable adverse effect level limitations, 405, 406 risk assessment, benchmark dose approach, 406 federal agency requirements, 385, 388 paradigms, 385387 regulatory issues, CADJPY scientific issues, 406408 risk-based study characteristics, 405 supernumary ribs, see Cervical supernumary ribs; Lumbar supernumary ribs testing guideline studies, 385390 Smads, mediation of bone morphogenetic protein signaling, 185, 186 Smart biomimetic matrices, intrinsic osteoconductivity, 222225 Smurfs, Smad degradation, 186 Sotos syndrome, candidate gene loci, 29 SOX9, mutation in skeletal disease, 27 Spastic paraplegia 9, candidate gene candidate gene loci, 29 loci, 29 Radioiodine Therapy for Thyroid Cancer 121 6.
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